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Interstitial Cystitis Study
The purpose of this study is to determine if having too many
bacteria in the small intestine is related to interstitial cystitis
(IC), and if treatment with a non-absorbable antibiotic called
Xifaxan will help. A significant percent of people with IC also have
gastrointestinal symptoms including bloating, gas, abdominal pain
and change of bowel habits. Recent studies have shown that people
who have these gastrointestinal symptoms frequently have small
intestinal bacterial overgrowth.
You can be eligible for the IC study if a breath test that reflects
bacterial overgrowth is positive.
To be eligible in this study you would need to have mild to
moderately severe interstitial cystitis or painful bladder syndrome
as determined by a urologist. The IC needs to be active with
symptoms of bladder or pelvic pain, urinary frequency and urgency.
The major conditions that would exclude you from participating in
the study include having the following: urine infection within 6
weeks, cystoscopy with Hunner’s ulcers in the bladder, bladder
stone, and implanted nerve stimulator that is activated. You would
need to wait 4-6 weeks if you have had cystoscopy, infusion
treatments, urethral dilatation, and antibiotics. Certain medicines
would need to be withdrawn before the study starts.
This study would involve coming to Dr. Leonard Weinstock’s office in
Creve Coeur for three visits over a period of two weeks. Two of
these visits will take 3 hours each and would include filling out
questionnaires, providing a urine sample, and a doing breath test. A
2-day voiding log (recording time and volume of urine voided) will
be done at home on two occasions. Two sets of questionnaires will be
filled out at home. Participants in the study will take the
antibiotic Xifaxan or placebo for 10 days. The chances of getting
the active medicine are two to one.
To see if you would be interested in participating in the study,
please read the consent form and if you are interested, please call
Michelle at 314-400-9912.
CONSENT FORM |